Presenilin 2 anticorps (N-Term)

N° du produit ABIN966891

Cet anticorps anti-Presenilin 2 est un anticorps Lapin Polyclonal détectant Presenilin 2 dans WB, IHC (p) et IHC (f). Adapté pour Humain. Ce Primary Antibody a été cité dans 3+ publications.

Aperçu rapide pour Presenilin 2 anticorps (N-Term) (ABIN966891)

Antigène: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Presenilin 2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Détail du produit anti-Presenilin 2 anticorps

Épitope: N-Term

Réactivité croisée: Souris, Rat (Rattus)

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Presenilin-2 ( PSEN2) detection. Tested with WB, IHC-P, IHC-F in Human, Mouse, Rat.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminal of human Presenilin-2, different from the related mouse and rat sequences by two amino acids.< br/>Immunogen was affinity purified.

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide, Thimerosal (Merthiolate)

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.

Références pour anticorps anti-Presenilin 2 (ABIN966891)

Hoek, Schlegel, Eichhoff, Widmer, Praetorius, Einarsson, Valgeirsdottir, Bergsteinsdottir, Schepsky, Dummer, Steingrimsson: "Novel MITF targets identified using a two-step DNA microarray strategy." dans: Pigment cell & melanoma research, Vol. 21, Issue 6, pp. 665-76, (2008) (PubMed).

Kaplan, Renbaum, Vreman, Wong, Levy-Lahad, Hammerman, Stevenson: "(TA)n UGT 1A1 promoter polymorphism: a crucial factor in the pathophysiology of jaundice in G-6-PD deficient neonates." dans: Pediatric research, Vol. 61, Issue 6, pp. 727-31, (2007) (PubMed).

Levy-Lahad, Wijsman, Nemens, Anderson, Goddard, Weber, Bird, Schellenberg: "A familial Alzheimer's disease locus on chromosome 1." dans: Science (New York, N.Y.), Vol. 269, Issue 5226, pp. 970-3, (1995) (PubMed).

Détails sur Presenilin 2

Antigène: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Autre désignation: Presenilin-2(PS-2)

Sujet: Presenilin-2 is a protein that in humans is encoded by the PSEN2 gene. [1]Kovacs et al. (1996) demonstrated that the expression patterns of PS1 and PS2 in the brain are extremely similar to each other and that messages for both are primarily detectable in neuronal populations. Immunochemical analyses indicated that PS1 and PS2 are similar in size and localize to similar intracellular compartments (endoplasmic reticulum and Golgi complex). Li et al. (1997) demonstrated that wildtype PS1 and PS2 are localized to the nuclear membrane, its associated interphase kinetochores, and the centrosomes. In melanocytic cells PSEN2 gene expression may be regulated by MITF. [2]

Pathways: Signalisation Notch, EGFR Signaling Pathway, Neurotrophin Signaling Pathway